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Under oxidative stress, the transcription factor Nrf2 (Nuclear Factor Erythroid 2-Related Factor 2) translocates from the cytoplasm into the nucleus and binds to the antioxidant response element (ARE)

Some are unwilling to budge and allow treatment even when faced with a tearful patient on their knees begging for treatment

However, hydropersulfides are superior to -tocopherol owing to their low H-bond acidity, a unique attribute of hydropersulfides, which makes their reactivity largely insensitive to changes in the surrounding medium 20

Sherwin E, Dinan TG, Cryan JF

10.1038/s41598-022-07317-x 61 HussainA.TangO.SunC.JiaX.SelvinE.NambiV.et al (2021)