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About this article Cite this article You, T., Peng, K., Zhao, K

10.1073/pnas.0600865103 Proc Natl Acad Sci U S A

This observation may reflect oxidative alterations that could potentially exacerbate neuronal injury or be involved in epilepsy pathophysiology 31

Therefore, there is still the need for the discovery and/or development of a drug candidate characterized by at least a comparable pain-relieving effect to opioids but with a much better safety prole in terms of expected adverse reactions

Which increase I would never have noticed, without a sleep tracker as I do not feel much different (sleep is my super power) but I do understand the benefit of increased DS that helps the glymphatic system in clearing out the detritus in the brain while we sleep