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Pharmaceuticals 16(10):1432 Steinmetz JD et al (2021) Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: the Right to Sight: an analysis for the Global Burden of Disease Study

Clinical trials exploring the use of NAC at doses as high as 3,000 mg per day for as long as 12 months in patients with chronic respiratory diseases have not detected any safety concerns (Calverley 2021)