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Glycotoxins, carbonyl stress and relevance to diabetes and its complications

Abbreviations ARI: Aripiprazole BDNF: Brain-derived neurotrophic factor BSO: L-buthionine-(S, R)-sulfoximine CAT: Catalase CpG: Cytosine-guanine Cys: Cysteine CBS: Cystathione -synthase DA: Dopamine ESC: Escitalopram GABA: Gamma-aminobutyric acid GBR: 12909 1-[2-[Bis-4(fluorophenyl)methoxy]ethyl]-4-3-(3-phenylpropyl) GCL: Glutamate-cysteine ligase GCLC: Glutamate-cysteine ligase catalytic subunit GCLM: Glutamate-cysteine-ligase modifier subunit GPx: Glutathione peroxidase GR: Glutathione reductase GSH: Glutathione GSSG: Glutathione disulfide Hcy: Homocysteine hpGPx: Human plasma glutathione peroxidase 5-HT: Serotonin MAO: Monoamine oxidase Met: Methionine MIR: Mirtazapine MST: Mercaptopyruvate sulfurtransferase NAC: N-acetylcysteine NMDA: N-acetyl- D -aspartate acid ODS: Osteogenic Disorder Shionogi ROS: Reactive oxygen species SAM: S-adenosyl-methionine SOD: Superoxide dismutase References Lewis DA, Lieberman JA

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( C ) ALOX15 KD lowers extracellular GSSG and restores a normal GSH:GSSG ratio ( n = 6)