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Demonstrates anti-inflammatory properties in lab studies, particularly via suppression of NF-B activity and cytokines such as TNF- , IL-6 , and IL-1

These include increased FFA flux from the adipose tissue to the systemic circulation, possibly leading to insulin resistance (Mller and & Jrgensen, 2009

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10.1016/S1474-4422(21)00464-6 Lancet Neurol

Incorporating MDSC checkpoint blockade into this type of regime would further enhance the immune response by reducing the immunosuppressive activity of MDSCs, allowing for greater CAR-T cell infiltration, improved T cell activation, and more effective anti-tumor response