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Approximately 80% of individuals with RBD will develop a neurodegenerative disease within 10.5 years of RBD diagnosis, and the plurality (43%) of those who convert will develop PD [31]

In terms of mechanism, BCL2L1 binds to and suppresses PGAM5, a phosphatase located in the mitochondria, thereby preventing the dephosphorylation of FUNDC1 at Ser-13