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Autophagy dysregulation is involved in the pathophysiology of DKD by increasing ROS production, mediating inflammatory responses and inducing renal cell damage and apoptosis (116, 117)

Developed by Novo Nordisk as a glucagon-like peptide-1 receptor agonist (GLP-1 RA), semaglutide emerged from efforts to create longer-acting diabetes medications with improved glycemic control and potential cardiovascular benefits

For some local diseases related to the skin or nervous system, such as skin nerve injury, local neuropathy, etc., cream formulations can directly deliver drugs to the affected area, increase the concentration of drugs locally, and enhance the therapeutic effect

Brain Res 537:298302

To address whether this is mediated by senescence-clearance, we again made use of the ability of the 3MR construct to eliminate senescent cells through GCV