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Continual microglia activation produces high contents of inflammatory molecules, such as IL-1, IL-6, and TNF-, and overproduces ROS and nitric oxide, resulting in chronic inflammatory responses that bring out neuronal death and brain injury [77, 78]

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Flavonoids were separated with an InfinityLab Poroshell 120, EC-C18 (2.1 50 mm, 2.7 m, Agilent) column at 30 C

Anti-musk Abs are thought to block the binding of other components, including collagen Q and low-density lipoprotein receptor-related protein 4 (LRP4) that facilitate the role of MuSK in the neuromuscular junction [149, 150]

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