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Notably, microtubule-associated protein light chain 3 (LC3) undergoes conjugation with phosphatidylethanolamine during autophagosome biogenesis, leading to the conversion of LC3 to its lipidated form LC3-II, which serves as a principal biomarker for autophagic flux quantification (108110)

doi:10.7205/milmed-d-01-7208

10.3390/cells10010051 116

Oxidation of dopamine and consequent quinone modification contribute to the vulnerability of dopaminergic neurons ( Mitochondrial Dysfunction Neuronal ATP formation depends on mitochondrial aerobic respiration, which normally produces hydrogen peroxide and superoxide radicals as byproducts during mitochondrial oxidative phosphorylation ( c , and eventually triggering apoptosis ( Neuroinflammation In response to neural tissue injury or toxic insult, microglial cells undergo activation as a self-defensive mechanism

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