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Excessive activation of the Ang II type 1 receptor induces NADPH oxidase, which is a major generator of ROS in vascular and CC, and elevated ROS level may diminish NO bioavailability

Mice that were given an mRNA vaccine expressing pre-fusion SARS-CoV-2 S protein developed neutralizing antibodies and S-protein-specific CD8 T cell responses that were protective against lung infection without evidence of immunopathology 116 , and neutralizing mAbs against the RBD of the S protein of SARS-CoV-2 reduced lung infection and cytokine release 117

M.et al (2005)

Beale RJ, Sherry T, Lei K, Campbell-Stephen L, McCook J, Smith J, et al

Yamashita et al