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Current strategies to enhance adipose stem cell function: an update

2013 Nov 1;13(23):1-45

14.2 Prevention of Postmenopausal Osteoporosis The efficacy and safety of Reclast in postmenopausal women with osteopenia (low bone mass) was assessed in a 2-year randomized, multi-center, double-blind, placebo-controlled study of 581 postmenopausal women aged greater than or equal to 45 years, who were stratified by years since menopause: Stratum I women less than 5 years from menopause (n=224)

The overwhelming body of research focuses on deficiency-related psychiatric symptoms rather than toxicity or adverse effects from adequate intake

The vast majority of data comes from in vivo studies conducted on murine and rat models, as well as in vitro experiments on cell cultures