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Dr David Perlmutter : Well, the the real trigger for the whole process was uric acid elevation as a downstream metabolite of fructose consumption, consuming those wild berries that our ancestors would come upon, that primates consume in preparation for hibernation, or I mean, for in preparation for winter, that bears consume in preparation for hibernation

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All systems in human body suffer from compromized mitochondrial health but the most affected are highly energy-consuming ones which are the heart, the central and peripheral nervous system, and skeletal and smooth muscles resulting in frequently fatal cardiac deficits (heart failure, sudden heart arrest), accelerated brain aging/neurodegeneration, and a spectrum of muscular pathologies