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Mechanistically, HIF-1 binds to hypoxia-response elements (HREs) within the PD-L1 promoter, enhancing its expression in both tumor cells and immunosuppressive myeloid populations such as macrophages and MDSCs, thereby reinforcing an immune-resistant TME [329]

For example, minoxidil is a topical medication that can help stimulate hair follicles, while finasteride is an oral medication that can block the hormone dihydrotestosterone (DHT), which is associated with male pattern baldness

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Rarer issues include vein inflammation (phlebitis), infection, allergic reactions and, in people with heart or kidney conditions, fluid overload

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