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At higher doses, the active metabolite teriflunomide also inhibits tyrosine kinases responsible for early T-cell and B-cell signaling

Without the copper, the peptide loses most of its biological activity

Formation of modified DNA bases induces mutagenic properties that could result in binding of transcription factors, alterations in replication of DNA, or appropriate base pairing producing mutations that could lead to altered protein synthesis (55)

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Finally, secretion and neurotrophic activity of PEDF under zinc stress conditions were investigated in retinal cells models using various approaches including flow cytometry, confocal microscopy, and targeted liquid chromatographymass spectrometry