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The role of ATP13A2 in Parkinsons disease: clinical phenotypes and molecular mechanisms

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Three CYP enzymes, CYP2D6, CYP3A4, and CYP3A5, showed the main activity of metabolizing risperidone to 9-hydroxyrisperidone, with activities of 7.5, 0.4, and 0.2 pmol pmol 1 CYP min 1 , respectively

Furthermore, declining hormone levels during the late luteal phase weaken the antioxidant capacity of the Nrf2 pathway while activating inflammatory signals, such as the COX-2/PGE2 axis, thus establishing a vicious cycle of "low hormone levelshigh oxidative stressstrong inflammation" [47]