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10.1002/ptr.5297 80 LuY.LiS.WuH.BianZ.XuJ.GuC.et al (2015b)

Approximately one decade ago, ATM kinase deficiency in Drosophila was reported to increase the gene expression of the innate immune response, 369 while ATM-deficient mice with unrepaired DSBs were found to induce Type I interferons (T1IFNs) via stimulator of interferon genes (STING)-dependent cytosolic DNA sensing pathways to enhance innate immunity against bacterial and viral infection

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Allowing the injectable solution to reach room temperature before injection decreases the temperature gradient between the medication and your skin, reducing thermal irritation signals