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Abbreviations AEDs: Antiepileptic drugs GABA: Gamma-aminobutyric acid CMA: Chaperone-mediated autophagy Vps34: Vacuolar sorting protein 34 IGF: Insulin-like growth factor AMPK: Adenosine monophosphate protein kinase PTEN: Phosphate and tensin homology IMPase: Inositol monophosphatase SIRT1: Sirtuin-1 mTORC1: mTOR complex 1 GSK3: Glycogen synthase kinase 3 FOXO3: Forkhead box o3 ROS: Reactive oxygen species NO: Nitric oxide PGC1: Peroxisome proliferator-activated receptor- coactivator 1- LPS: Lipopolysaccharide NSAID: Non-steroidal anti-inflammatory drug COX: Cyclooxygenase References Aguiar CCT, Almeida AB, Arajo PVP, Abreu RNDCd, Chaves EMC, Vale, OCd et al

doi: 10.3389/fonc.2020.536377 25 StewartJSCohenEELicitraLVan HerpenCMKhorprasertCSoulieresDet al