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Mitochondrial dysfunction is a key factor driving epithelial cell death: Drp1-mediated excessive mitochondrial fission leads to ROS accumulation and apoptosis, while steroidogenic acute regulatory (StAR) protein-related lipid transfer (START) domain-containing protein 7 (STARD7) protects barrier function by maintaining mitochondrial membrane stability [75, 76]

Appetite increase can be significant in the first few weeks due to ghrelin activation

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Growth hormone exerts an anti-catabolic effect during energy restriction, helping preserve lean mass. Jrgensen, J.O.L., Growth Hormone & IGF Research 3

Their unique combination of specificity, safety, and biological relevance positions them at the forefront of drug developmentbridging the gap between natural biological processes and cutting-edge therapeutic innovation