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There are counteracted muscle wasting, significantly corrected deranged muscle proliferation as well as myogenesis, counteracted increase of the proinflammatory cytokines such as IL-6 and TNF-, looking at muscle metabolism relevant to cancer cachexia as well as the changes in the expression of FoxO3a, p-AKT, p-mTOR, and P-GSK-3 (Kang et al., 2018)

Notably, the lack of protective effect of MitoTEMPO is cell line-dependent, as it partially resuces BSO-induced cytotoxicity in HT1080 cells, a fibrosarcoma cell line

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Due to the limited data, it should be avoided by anyone who is pregnant, breastfeeding, or undergoing active cancer treatment