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This suggests that any disruption of the microbial functions following RT may contribute to some neuropsychological symptoms like fatigue, depression, and cognitive dysfunction (Zhang Y

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551,552 Clinical progress and challenges At present, there are more and more clinical trials regarding mitochondria-targeted therapies, covering different disease directions, especially diseases related to mitochondrial dysfunction, such as cancers, motor muscle diseases, neurodegenerative diseases, cardiovascular diseases, metabolic diseases, and rare mitochondrial diseases