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EXS 99, 87110 (2009)

By reflecting underlying inflammatory and fibrotic pathways common to myocardial injury, renal fibrosis, endothelial dysfunction, and metabolic disturbances, galectin-3 integrates these pathologies into a unified concept of multisystem organ dysfunction

Its importance in modern days relates to the generally greater toxicity and stress than the human has seen in many ages, if ever, combined w a generally pitiful intake of healthy foods (compared to higher human and other animal norms) combined with heightened physiological including environmental stresses and related factors

Right panels: 300 ms exposure

Oxidative damage Oxidative stress is increased by: Liver hypermetabolism, caused by alcohol consumption Free radicalinduced lipid peroxidative damage Reduction in protective antioxidants (eg, glutathione, vitamins A and E), caused by alcohol-related undernutrition Binding of alcohol oxidation products, such as acetaldehyde, to liver cell proteins, forming neoantigens and resulting in inflammation Accumulation of neutrophils and other white blood cells (WBCs), which are attracted by lipid peroxidative damage and neoantigens Inflammatory cytokines secreted by WBCs Accumulation of hepatic iron, if present, aggravates oxidative damage