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Breast cancer cells acquire resistance through pathways such as downregulation of HER-2 expression and upregulation of ABC transporter protein expression 90

These mutations also increased the binding affinity of rat amylin(2737) for calcitonin receptor ECD similarly to the affinity increases shown for the amylin receptor ECDs (Figure 1D and Table 2) making rat amylin(2737) with L27Y and Y37P double mutations non-selective for either amylin receptor ECD or calcitonin receptor ECD

Ther Adv Chronic Dis (2021) 12_suppl:2040622321995691

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For CellTox assay error bars represent SEM