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Polymorphisms in TNFAIP3 and elevated levels of circulating proteasomes are also associated with RA, further implicating the UPS in disease pathogenesis

The additional ELISA and HPLC data generated in this study are also provided in the Supplementary Information/Source Data file

PLoS One 5(7):e11838 Itoh K, Wakabayashi N, Katoh Y, Ishii T, Igarashi K, Engel JD et al (1999) Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Actions on cellular metabolism The effects of melatonin in regulating the function of mitochondria allow it to have anticancer properties

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