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Regarding the preclinical studies, this review revealed several shortcomings

Selvarajan S, Lund LR, Takeuchi T, Craik CS, Werb Z

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To simplify clearance of the bile duct with laparoscopic techniques and decrease the barriers to the incorporation of LC with IOC LCBDE in the pediatric population, we have developed a Seldinger-based technique for LCBDE that uses easy-to-source disposable pieces of equipment and culminates with an over-the-wire balloon dilation of the Sphincter of Oddi with antegrade flushing of stones

2 Excessive Dosing 2 Excessive Dosing Some people believe more is better. High, unsupervised doses of any compound even vitamins can stress the body