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Abbreviations CVD: Cardiovascular disease HF: Heart failure HFrEF: Heart failure with reduced ejection fraction IV: Intravenous ID: Iron deficiency TSAT: Transferrin saturation FCM: Ferric carboxymaltose DCYTB: Duodenal cytochrome B CRT: Cardiac resynchronization therapy CMR: Cardiac magnetic resonance ROS: Reactive oxygen species ATP: Adenosine triphosphate Fe: Iron FPN: Ferroportin sTfR: Soluble transferrin receptor TIBC: Total iron-binding capacity HIF: Hypoxia-inducible factor IL: Interleukin eNOS: Endothelial nitric oxide synthase HFE: Hemochromatosis gene AHA: American Heart Association ACC: American College of Cardiology HFSA: Heart Failure Society of America ESKD: End-stage kidney disease References WHO

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The patient experienced a complete normalization of aminotransferases and negative auto-antibody titers within 3 months of statin discontinuation without any further intervention

The lack of changes in muscle strength may have been influenced by physical activity, since the group of participants was characterized by relatively high physical activity

Case 5 A 15-year-old female patient presented with 6 days history of difficulty in walking with feeling of cotton wool-like sensation over sole while walking