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Specific neurological symptoms usually then follow, often in the form of parkinsonism (lead-pipe or cogwheel rigidity, bradykinesia, and postural instability [8] ) with or without a typical hand tremor, masked facial expressions, slurred speech, ataxia (lack of coordination), or dystonia (twisting and repetitive movements of part of the body)

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[82] show that inhibiting cyclin-dependent kinase 5 is expected to break the awkward situation

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