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Mapping of the tyrosine kinase receptors trkA (NTRK1), trkB (NTRK2) and trkC (NTRK3) to human chromosomes 1q22, 9q22 and 15q25 by fluorescence in situ hybridization

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Cagrilintide acts as a potent agonist at these complexes, activating Gs-coupled adenylyl cyclase and elevating intracellular cAMP, with downstream PKA activation and CREB-mediated transcriptional effects

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