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Evidence demonstrates that Soluble A oligomers are able to block the EAAC1-mediated cysteine uptake leading to a GSH loss in cultured human neuronal cells [81]

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Habib et al., Whether an activation of xCT transporter function due to an increased substrate availability and/or an increased xCT expression plays a role in the NAC-induced reduction of hippocampal GSSG/GSH ratio, the administration of the xCT inhibitor SZ was expected to reduce or block such an effect of NAC