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Huberman notes that there has been significant research confirming this effect, such as a randomized controlled trial that found a 20% reduction in cortisol, and a 40% reduction in perceived stress, compared to the placebo group 18 A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults Chandrasekhar et al

10.1186/s40478-016-0324-5 322 SwarupV.PhaneufD.DuprN.PetriS.StrongM.KrizJ.et al

The arginine substitution at position 3 and the N-terminal extension collectively reduce IGFBP affinity by approximately 1001,000-fold in preclinical binding assays

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10.1146/annurev.immunol.22.012703.104644 [DOI] [PubMed] [Google Scholar] Wick G., Jakic B., Buszko M., Wick M