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(2013), Guidance for industry and FDA staff

These mutations are common- about 4 in 10 of the general population carry them

6 (7), e1000097

In only three cases did vB12 treatment rebalance a metabolic alteration observed in untreated Tbx1 +/ mice, namely, inosine, glutamate, and short-chain fatty acids (SCFAs) (Figs 4C and S3B)