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However, GSH levels tend to decrease with aging and in various age-related neurodegenerative diseases, especially Alzheimers disease, the most prevalent form of dementia affecting the elderly 11,12,13

Their mechanisms of action are rich and diverse, covering aspects such as interfering with cell wall/membrane synthesis, inhibiting virulence factors, disrupting energy metabolism, and regulating fungal signaling pathways (Lu et al., 2024

Similarly, DNA methyltransferase (DNMT) inhibitors alleviate depressive-like behaviors in ethanol-exposed rodents by demethylating BDNF promoters, underscoring the therapeutic potential of epigenetic editing (Shivakumar et al

Celastrols mechanisms of action involved enhancing antioxidant capacity and reducing iron deposition through the SIRT1/NRF2/GPX4 signalling pathways

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