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Non-enzymatic antioxidants function through several mechanisms: Direct radical scavenging : Neutralizing free radicals by donating electrons or hydrogen atoms Metal chelation : Binding transition metals like iron and copper that catalyze free radical generation Quenching : Absorbing and dissipating the energy from reactive oxygen species Chain-breaking : Interrupting chain reactions of lipid peroxidation Regeneration : Recycling other antioxidants back to their active forms Unlike enzymatic antioxidants that catalyze multiple reactions without changing, non-enzymatic antioxidants become oxidized during their protective action and require regeneration

1.1.4 Plant based diets Growing evidence supports the role of plant-based dietary patterns in preventing AD and Alzheimers disease-related dementias (ADRD), through both direct neuroprotective effects and modulation of systemic risk factors (Kheirouri et al., 2024)

doi: 10.1189/jlb.4A0616-282RR

Free Radic Biol Med 49:16171628 Cooper AJL, Pulsinelli WA, Duffy TE (1980) Glutathione and ascorbate during ischemia and postischemic reperfusion in rat brain

Using ACEIs can counteract these negative effects and may reduce the risk of MI associated with high plasma levels of ang-II