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Although ferroptosis, an iron-dependent form of cell death, has numerous pathophysiological features similar to those of SLE, such as intracellular iron accumulation, mitochondrial dysfunction, lipid metabolism disorders and concentration of damage associated-molecular patterns (DAMPs), only a few reports have demonstrated that ferroptosis is involved in SLE progression and that the role of ferroptosis in SLE pathogenesis continues to be neglected

If more than 48 hours have passed, skip that dose and administer your next regular injection at the planned time

doi: 10.1016/S0098-2997(01)00010-3 31 XieQWChoHJCalaycayJMumfordRASwiderekKMLeeTDet al

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Finally, the collected cells were incubated with JC-1 (10 mM) in the dark at 37 C for 30 min