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Description

Semax is generally chosen for focus, motivation, and clearing brain fog, while Selank is often described as the more directly calming, anti-anxiety option

J Chem Neuroanat 128:102210

The mechanism appears to involve increased serotonin synthesis in substantia nigra (both compacta and reticulata), a regional pattern unlike any existing antidepressant drug, plus potential dopaminergic contributions given the nigrostriatal location