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While this patient has lung findings, the bilateral hilar lymphadenopathy and interstitial infiltrates strongly favor sarcoidosis over a primary squamous cell lung malignancy

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Additional metabolites such as capsiate (which activates TRPV1 to upregulate Gpx4 and inhibit ferroptosis)[21], petroselinic acid (which activates the AMPK-mTOR pathway to suppress apoptosis)[173], and Indole-3-lactic acid (which enhances epithelial stem cell function through YAP and Nrf2 activation and protects the gut-vascular barrier through AhR/Nrf2/STAT3-mediated claudin-2 downregulation)[174, 175]

J Clin Oncol 30(suppl 4), 2012

Further studies are required to decipher the complex regulation of expression of different isoforms of the AsA-GSH pathway enzymes in order to bolster our understanding of ROS homeostasis in plants