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Yes, in some cases, HER2 status can change as the disease evolves or after treatment, meaning a tumor may later test as HER2-negative or show reduced HER2 expression

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10.1146/annurev.arplant.57.032905.105406 Annu

In this study, we demonstrate that human albumin requires a branched or medium-long aliphatic amino acid in the C-terminal end at position 585 for optimal binding to human FcRn, and that the L585 residue can not be substituted with an amino acid unrecognizable by CPA without compromising receptor binding