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Tesamorelin works by stimulating the pituitary gland to increase the natural production of HGH (Human Growth Hormone)

doi: 10.1038/s42003-022-03485-8 120 KernsKZigoMSutovskyP

The condition affects roughly 1 to 3% of the general adult population, with peak incidence occurring between ages 30 and 50

Cushing, V

Consistently, a complementary strategy showed that in aged mice, where IGF-I levels are decreased, cardiac overexpression of IGF-I significantly improved cardiomyocyte contractile function[283], attenuating oxidative stress-mediated protein damage, normalizing Ca 2+ homeostasis, reversing age-related alterations in the expression of pro-apoptotic proteins, and decreasing the apoptosis rate[284]