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In CCs, the unfolded protein response (UPR) resulting from ER stress prompts the activation of PERK/ATF4 signaling that in turn activates a positive feedback loop, upregulating VEGF at the transcriptional level, both by inducing the VEGF promoter and increasing VEGF mRNA stability [119]

Ilhan H, Wang H, Gildehaus FJ, Wangler C, Herrler T, Todica A, et al

The effects of alpha-lipoic acid supplementation on glucose control and lipid profiles among patients with metabolic diseases: A systematic review and meta-analysis of randomized controlled trials