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Oxidative stress, generated by activated immune cells, produces reactive oxygen species (ROS) and nitric oxide, causing DNA damage in gametes and embryos, reducing sperm motility, and impairing fertilization ( 2.3 Oxidative stress and ferroptosis in endometriosis Ferroptosis, a novel iron-dependent programmed cell death characterized by the accumulation of lipid peroxides, is distinct from apoptosis, necrosis, and autophagy, and has been closely linked to female infertility, including endometriosis-associated infertility ( 2+ + H 2 O 2 Fe 3+ + OH + OH), producing highly toxic hydroxyl radicals that target lipids, proteins, and nucleic acids, thereby exacerbating oxidative stress

Studies on morphological changes of the basal ganglia and thalamus in bipolar disorder are both sparse and contradictory (87, 107)

PE-22-28 treatment induced hippocampal neurogenesis after only 4 days, as measured by BrdU incorporation and doublecortin staining