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This was first shown by adding NO donors to the isolated mitochondria (149, 150) and later by showing that NOS inhibition was associated with enhancement of oxygen consumption in the resting muscles of dogs and other organs (151, 152)

In addition to AD and PD/LBD, GRN variation has also been implicated in Gaucher disease [57], FTLD-TDP and/or motor neuron disease with C9orf72 repeat expansions [58], ALS [59], and limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) [60]

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Given that ATMi reduces the ability to upregulate aerobic respiration, we considered the possibility that this may be the result of altered TCA cycle and electron transport chain (ETC) use