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5 Targeting and delivery strategies of NPs for PD For the successful treatment of PD by NPs, there are two important features: firstly, effective targeting and delivery

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QE also decreased TGF- levels and HSC activation and promoted degradation of the extracellular matrix by increasing metalloproteinases (Casas-Grajales et al., 2017)

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After reaching 70% confluence, fibroblasts were cultured for 24 h in 1% FBS DMEM and then incubated with either TGF1 10ng/ml (Peprotech, Dollard des Ormeaux, Quebec, Canada), GHK 10 nM (Sigma, Markham, Ontario, Canada) or control media (1% FBS DMEM, penicillin, streptavidin) for a further 48 h