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A 2018 review by Sikiric described its effects on the VEGF pathway, which drives the formation of new blood vessels (angiogenesis), and on the nitric oxide system, which regulates blood flow and inflammation

Am J Physiol Endocrinol Metab 307:E326E334 Wolf I, Shahmoon S, Ben Ami M, Levy-Shraga Y, Mazor-Aronovitch K, Pinhas-Hamiel O, Yeshayahu Y, Hemi R, Kanety H, Rubinek T, Modan-Moses D (2014) Association between decreased klotho blood levels and organic growth hormone deficiency in children with growth impairment

Once they recover, which is typically within seven to ten days, they can resume their normal activities

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