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Folic acid can lead to a decrease in DNMT3a expression, which downregulates the methylation level of the forkhead Box P3(FOXP3) promoter region, thereby increasing the abundance of FOXP3 expression, an important transcription factor for Treg cells, which can alleviate liver inflammatory injury in ALD

Lack of animal models of CCA recapitulating the hepatic microenvironment of progressive sclerosing cholangitis hinders development of novel treatments