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The total effects of the met-a-308, met-a-337, and met-a-584 instrumental variable sets did not show significant deviations

But, this could also be explained by Simpson's Paradox: The national aggregate death count driven down by more substantial decreases in larger population states, while some states are going up

Biochem Pharmacol (2005) 70(2):2008

In addition, the energy required to break the Cu 2+ /imidazolyl coordination bond is not the lowest in comparison to Cu 2+ /carboxyl and Cu 2+ /amino coordination, leading to a negative impact on the catalytic activity also 28,29

More testing and research is needed before the scientists can determine if the same kind of treatment could be used in humans.