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Several studies have demonstrated the inhibitory effects of reactive astrocytes on CNS regeneration

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The strongest published finding is from the foundational Biochemical Pharmacology study by Neelakantan et al.: in diet-induced obese mice, daily 5-Amino-1MQ administration produced reductions in body weight, white adipose tissue mass, and adipocyte size without any significant change in food intake

Presumably, this environment provides protection against undesirable sidereactions involving the very reactive thiol