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2 Materials and methods 2.1 Protein structures and evaluation The hMRP1 ( and hMRP7 ( structures were predicted using AlphaFold ( Evaluation of the AlphaFold predicted model protein structures was performed using pLDDT (predicted Local Distance Difference Test) (Sippl, 1993), ERRAT (Williams et al., 2018)) integrated within the SWISS-MODEL workspace (Waterhouse et al., 2018)

The percentage of subjects receiving OCA 25 mg that achieved the primary endpoint was 23.8% among those with baseline GLP-1 RA use, 21.6% of those who added a GLP-1 RA, and 22.4% in the overall ITT population, compared to 4.3%, 7.5%, and 9.6% receiving placebo, respectively (Figure 1)

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We tested this idea using genetic and pharmacological inhibition of TS activity

The dietary flavonoid rhamnetin inhibits both inflammation and excitotoxicity during ethanol withdrawal in rat organotypic hippocampal slice cultures