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Only under the assumption of the high IC 50 of 200 mM (61.85 mg/mL) the lack of CYP3A4 inhibition could be a problem of drug concentration, but this is probably not of clinical relevance, since 400 mg per day is already a relatively high dose

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In contrast, no significant difference in the expression of all other analyzed ABC transporters was found between these patient groups (Supplementary Fig