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14 In the linear regression test (Table 3), beta coefficient ( = - 0.62) was obtained, indicating a strong significant negative effect between MASI score and plasma GSH levels in the Melasma Subject

However, the causal relationship between decreased GABA levels and gut dysbiosis in diabetes remains unclear: whether microbiota dysbiosis causes reduced GABA or hyperglycemia directly inhibits GAD activity requires further experimental verification