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Description

By altering histone acetylation and DNA methylation patterns, these dietary compounds can modify chromatin structure and influence the expression of genes involved in stress resistance, inflammation, and longevity, thereby conferring a durable adaptive advantage

Laboratory studies may show increased intraerythrocytic 2,3-diphosphoglycerate (2,3-DPG) levels and decreased levels of other erythrocyte enzymes

Accessed April 1, 2018

Am J Hum Genet 42:422434 Pomerantz DJ, Ferdinandusse S, Cogan J, Cooper DN, Reimschisel T, Robertson A, Bican A, McGregor T, Gauthier J, Millington DS, Andrae JLW, Tschannen MR, Helbling DC, Demos WM, Denis S, Wanders RJA, Newman JN, Hamid R, Phillips JA III, UDN Co (2018) Clinical heterogeneity of mitochondrial NAD kinase deficiency caused by a NADK2 start loss variant