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Therefore, to demonstrate whether adipocytes can undergo apoptosis in response to oxidative stress, one study treated mature adipocytes with H 2 O 2 and found that an increase in ROS enhanced adipocyte apoptosis (80)

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Imidazole ketone Erastin (IKE) achieves markedly greater potency and stability through an imidazole ketone scaffold that enables durable target engagement while resisting metabolic clearance (76)